August 18, 2014
Basic concepts about lactose
Basic concepts:
• Lactose = Lactase enzyme needed to process lactose
• Lactose intolerance = inability to process lactose
Today, we meet with rather secondary lactase deficiency, due to frequent disease of the small intestine, where there are changes in the structure of the mucosa, a lot going on infectious diseases. Lactase enzyme is vulnerable small intestine mucosa. Genetic isolation may still be missing such as sucrase, etc..
When there is no milk sugar lactose due to the lack of the enzyme hydrolyzed in the small intestine, it is moved down into the large intestine and there develops its osmotic action consequently, releasing water into the intestinal lumen. Osmotic effects are additionally increased by colon bacteria digested milk sugar fatty acid with a short chain, which then generate an acidic pH of faeces. This leads to the so-called osmotic diarrhea with huge bloating and abdominal cramps
Determine next diagnosis of clinical manifestations also elimination - exposure test (CST), evaluation was carried out before blood glucose levels for 15-30-60 and 90 minutes after drinking the solution, 50 ml of lactose in 500 ml of water. Evidence of lactase deficiency is the rise of blood glucose less than 1 mmol / l. Diagnosis then also added intestinal biopsy.
Today, the use of modern, non-invasive procedure - breath tests, both H2 test (breath hydrogen test), where in the exhaled air increases the concentration of hydrogen resulting bacterial decomposition undigested lactose in the colon and stable carbon isotope 13C, after administration of 13C-labeled - lactose or a combination of both.
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• Lactose = Lactase enzyme needed to process lactose
• Lactose intolerance = inability to process lactose
Today, we meet with rather secondary lactase deficiency, due to frequent disease of the small intestine, where there are changes in the structure of the mucosa, a lot going on infectious diseases. Lactase enzyme is vulnerable small intestine mucosa. Genetic isolation may still be missing such as sucrase, etc..
When there is no milk sugar lactose due to the lack of the enzyme hydrolyzed in the small intestine, it is moved down into the large intestine and there develops its osmotic action consequently, releasing water into the intestinal lumen. Osmotic effects are additionally increased by colon bacteria digested milk sugar fatty acid with a short chain, which then generate an acidic pH of faeces. This leads to the so-called osmotic diarrhea with huge bloating and abdominal cramps
Determine next diagnosis of clinical manifestations also elimination - exposure test (CST), evaluation was carried out before blood glucose levels for 15-30-60 and 90 minutes after drinking the solution, 50 ml of lactose in 500 ml of water. Evidence of lactase deficiency is the rise of blood glucose less than 1 mmol / l. Diagnosis then also added intestinal biopsy.
Today, the use of modern, non-invasive procedure - breath tests, both H2 test (breath hydrogen test), where in the exhaled air increases the concentration of hydrogen resulting bacterial decomposition undigested lactose in the colon and stable carbon isotope 13C, after administration of 13C-labeled - lactose or a combination of both.
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